ParkinsonCanadaV1, Main, Exploration, bibRecord, 000882

Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial.

Identifieur interne : 000882 ( Main/Exploration ); précédent : 000881; suivant : 000883

Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial.

Auteurs : Robert A. Hauser [États-Unis] ; C Warren Olanow [États-Unis] ; Karl D. Kieburtz [États-Unis] ; Emmanuelle Pourcher [Canada] ; Any Docu-Axelerad [Roumanie] ; Mark Lew [États-Unis] ; Olexandr Kozyolkin [Ukraine] ; Ann Neale [États-Unis] ; Chris Resburg [États-Unis] ; Uwe Meya [États-Unis] ; Christopher Kenney [États-Unis] ; Stephen Bandak [États-Unis]

Source :

The Lancet. Neurology [ 1474-4465 ] ; 2014.

RBID : pubmed:25008546

English descriptors

KwdEn :
- Adenosine A2 Receptor Antagonists (adverse effects), Aged, Antiparkinson Agents (adverse effects), Benzothiazoles (adverse effects), Cross-Over Studies, Double-Blind Method, Dyskinesia, Drug-Induced (diagnosis), Dyskinesia, Drug-Induced (epidemiology), Female, Humans, Internationality, Levodopa (adverse effects), Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (epidemiology).
MESH :
- chemical , adverse effects : Adenosine A2 Receptor Antagonists, Antiparkinson Agents, Benzothiazoles, Levodopa.
- diagnosis : Dyskinesia, Drug-Induced, Parkinson Disease.
- drug therapy : Parkinson Disease.
- epidemiology : Dyskinesia, Drug-Induced, Parkinson Disease.
- Aged, Cross-Over Studies, Double-Blind Method, Female, Humans, Internationality, Male, Middle Aged.

Abstract

Many patients with Parkinson's disease have motor fluctuations despite treatment with available drugs. Tozadenant (SYN115) is an oral, selective adenosine A2A receptor antagonist that improves motor function in animal models of Parkinson's disease. We aimed to assess the safety and efficacy of tozadenant as an adjunct to levodopa in patients with Parkinson's disease who have motor fluctuations on levodopa.

DOI: 10.1016/S1474-4422(14)70148-6
PubMed: 25008546

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Many patients with Parkinson's disease have motor fluctuations despite treatment with available drugs. Tozadenant (SYN115) is an oral, selective adenosine A2A receptor antagonist that improves motor function in animal models of Parkinson's disease. We aimed to assess the safety and efficacy of tozadenant as an adjunct to levodopa in patients with Parkinson's disease who have motor fluctuations on levodopa.</div>
</front>
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La maladie de Parkinson au Canada (serveur d'exploration)

Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial.

Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.